Efficacy of anagliptin as compared to linagliptin on metabolic parameters over 2 years of drug consumption: A retrospective cohort study

doi:10.4239/wjd.v9.i10.165

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World Journal of Diabetes

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Retrospective Cohort Study

World J Diabetes. Oct 15, 2018; 9(10): 165-171
Published online Oct 15, 2018. doi: 10.4239/wjd.v9.i10.165

Table 3 Changes in clinical parameters after starting the dipeptidyl peptidase-4 inhibitors therapy

	Anagliptin				Linagliptin
	3 mo	6 mo	12 mo	24 mo	3 mo	6 mo	12 mo	24 mo
Weight (kg)	64.5 (16.2)	65.4 (15.7)	64.7 (15.5)	63.7 (16.4)	66.1 (15.1)	66 (16.9)	67.3 (14.2)	66.4 (14.8)
SBP (mmHg)	128.6 (17.2)	128.2 (14.8)	126.8 (16.6)	130.1 (16.6)	129.3 (17.7)	127.1 (16.4)	128.9 (19.1)	124.9 (16)
DBP (mmHg)	70.7 (11.4)	70.9 (9.9)	69.4 (12.1)	69.1 (9.5)^b	70.7 (11.4)	69.3 (10.8)	72.5 (11.2)	70.2 (8.6)
AST (U/L)	22.5 (9.6)	22.4 (8.8)	22.3 (10)	23.8 (12.3)	22.7 (12.7)	24.9 (17.1)	23.2 (13.1)	23.7 (12.4)
ALT (U/L)	23 (14.9)^b	23 (14.8)^a	22.6 (15.7)^b	25.5 (18)	23.5 (12.9)	24.8 (14.8)	24 (13.9)	23.7 (15.4)
Cr (mg/dL)	0.74 (0.18)	0.77 (0.2)	0.77 (0.21)	0.77 (0.2)	0.85 (0.33)	0.86 (0.4)	0.9 (0.5)	0.84 (0.38)^d
PG (mmol/L)	8.96 (3.4)^a	8.8 (2.9)	8.91 (3.16)	9.12 (4.19)^b	9.54 (3.82)^d	9.28 (3.85)^d	9.48 (3.28)^d	9.51 (3.5)^b
HbA1c (mmol/L)	9.3 (2.3)^d	9.4 (2.1)^d	9.3 (1.8)^b	9.7 (1.9)^b	9.3 (2)^b	9.1 (1.8)^d	9.6 (2.2)^d	9.2 (1.8)^d
T-C (mmol/L)	5.11 (0.87)	5.11 (0.78)^b	5.19 (0.69)	5.03 (0.64)	5.11 (0.86)	5.14 (0.89)	5.31 (0.97)	5.09 (0.81)
TG (mmol/L)	1.83 (2.05)	1.73 (1.71)	1.64 (0.92)	1.51 (0.83)	2.1 (1.74)	1.85 (1.23)	2.11 (1.83)	1.76 (1.19)
HDL-C (mmol/L)	1.32 (0.3)	1.31 (0.32)	1.29 (0.27)	1.4 (0.37)	1.31 (0.37)	1.35 (0.42)	1.31 (0.34)	1.39 (0.38)^a
LDL-C (mmol/L)	3 (0.8)	3.07 (0.78)	3.13 (0.7)	2.96 (0.53)	2.85 (0.86)	2.94 (0.83)	3.04 (0.86)	2.91 (0.75)
UACR (mg/gCr)	40.7 (76.8)	-	-	-	23.8 (34.9)	-	-	-

Superscripts indicate statistically significant changes from baseline:

^aP < 0.05;

^bP < 0.01;

^dP < 0.001.

SBP: Systolic blood pressure; DBP: Diastolic blood pressure; AST: Aspartate transaminase; ALT: Alanine aminotransferase; Cr: Creatinine; PG: Plasma glucose; HbA1c: Hemoglobin A1c; T-C: Total cholesterol; TG: Triglyceride; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; UACR: Urinary albumin creatinine ratio.

Citation: Hamasaki H, Hamasaki Y. Efficacy of anagliptin as compared to linagliptin on metabolic parameters over 2 years of drug consumption: A retrospective cohort study. World J Diabetes 2018; 9(10): 165-171
URL: https://www.wjgnet.com/1948-9358/full/v9/i10/165.htm
DOI: https://dx.doi.org/10.4239/wjd.v9.i10.165