Expression of matrix metalloproteinase-11 is increased under conditions of insulin resistance

Figure 3 Intraperitoneal insulin tolerance test and the expression of matrix metalloproteinase-11, collagen type VI alpha 3 and fibroblast-specific protein 1 in mice under different dietary conditions. A: IITT. Insulin tolerance was assessed in 12 h fasted mice, intraperitoneally injected with insulin (0.25 U/kg body weight). LFD (n = 6); HFD (n = 10). ^bP < 0.01 vs LFD; B: MMP-11, Col6α3 and FSP-1 mRNA expression in WAT of mice fed a low-fat (LFD) or high-fat (HFD) diet (n = 6 per each group). Results are the means ± SE of three independent measurements from each animal. ^dP < 0.001 vs LFD, for each group. MMP-11: Matrix metalloproteinase-11; IITT: Intraperitoneal insulin tolerance test; Col6α3: Collagen type VI alpha 3; FSP-1: Fibroblast-specific protein 1.