Copyright
©The Author(s) 2017.
World J Diabetes. Jul 15, 2017; 8(7): 330-336
Published online Jul 15, 2017. doi: 10.4239/wjd.v8.i7.330
Published online Jul 15, 2017. doi: 10.4239/wjd.v8.i7.330
Genetic background | Spontaneous autoimmunity1 | AAbs | T1D | B cells | T cells | Ref. | |
PTPN22 knock-out | C57BL/6 | No | No | No | intact | ↑Memory/effector number ↑Treg number and function ↑TFH number and function ↑Tr1 number and function | [72-75,84] |
PTPN22 knock-out | RIP-LCMV (B6) | No | No | Exacerbated | Not examined | ↑Effector function | [81] |
PTPN22 R619W knock-in | C57BL/6 | No | No | No | Not examined | ↑Memory/effector number | [68] |
PTPN22 R619W knock-in | C57BL/6 x 129 | Lupus-like disease | Yes | No | ↑Transitional and Self-reactive | ↑Memory/effector number | [67] |
PTPN22 R619W transgenic | C57BL/6 | No | No | No | Not examined | No differences | [77] |
PTPN22 knock-down | NOD | No | No | Protected | ↑Activation | ↑Treg number and function | [78] |
PTPN22 transgenic | NOD | No | No | Protected | Not examined | ↓Memory/effector number | [79] |
PTPN22 R619W knock-in | NOD | No | ↑↑ | Exacerbated | Not examined | Not examined | [76] |
- Citation: Galvani G, Fousteri G. PTPN22 and islet-specific autoimmunity: What have the mouse models taught us? World J Diabetes 2017; 8(7): 330-336
- URL: https://www.wjgnet.com/1948-9358/full/v8/i7/330.htm
- DOI: https://dx.doi.org/10.4239/wjd.v8.i7.330