Interleukin-18 polymorphism as an inflammatory index in metabolic syndrome: A preliminary study

Table 4 Stratification of study subjects according to genotype distribution

Variables	CC (n = 57)	AC (n = 72)	AA (n = 51)	P value
BMI (kg/m2)	23.36 ± 4.05	24.60 ± 4.137	25.25 ± 3.351	0.05
Body fat (%)	24.70 ±10.30	28.70 ± 8.592	29.31 ± 9.461	< 0.001
Waist circumference(cm)	92.78 ± 16.61	96.48 ± 13.21	97.32 ± 13.82	0.085
Hip circumference (cm)	74.18 ± 4.23	67.40 ±3.99	64.51 ± 4.84	0.694
WHR (cm)	0.88 ± 0.069	0.88 ± 0.061	0.89 ± 0.06	0.490
Fasting blood glucose (mg/dL)	103.41 ± 23.43	101.79 ± 21.01	110.32 ± 21.97	> 0.05
Insulin (uIU/mL)	28.83 ± 11.91	32.76 ± 11.392	34.67 ± 9.611	0.002
HOMA-IR	7.75 ± 4.34	8.44 ± 3.71	9.47 ± 3.001	0.007
QUICKI	0.29 ± 0.02	0.28 ± 0.02	0.28 ± 0.011	0.046
Cholesterol (mg/dL)	161.01 ± 39.01	165.12 ± 55.03	177.42 ± 60.72	> 0.05
Triglyceride (mg/dL)	135.66 ± 42.29	145.61 ± 61.45	146.78 ± 64.08	> 0.05
HDL(mg/dL)	38.29 ± 8.84	38.48 ± 56.32	37.17 ± 6.75	> 0.05
LDL(mg/dL)	88.99 ± 5.38 (SEM)	94.73 ± 6.63 (SEM)	107.77 ± 7.89 (SEM)	> 0.05
TNFα (pg/mL)	2521 ± 353.9 (SEM)	3403.08 ± 313.25 (SEM)	3760.35 ± 336.551 (SEM)	0.008
IL-18 (ng/L)	37.16 ± 19.35	43.00 ± 13.192	46.311 ± 13.071	0.001

¹AA vs CC;

²AC vs CC. HDL: High density lipoprotein; LDL: Low density lipoprotein; TNFα: Tumor necrosis factor alpha; IL-18: Interleukin-18.