Management of critically ill patients with diabetes

Table 3 Strict glycemic control vs moderate glycemic control in critically ill patients with diabetes

Ref.	Study design/cohort	Sample size	Control group	Therapies employed	Conclusion	Favored therapy
Lecomte et al[57] (2011)	Diabetics undergoing off-pump cardiac bypass surgery	60	Matched 60 non-diabetics	Strict glycemic control (80-110 mg/dL)	Strict glycemic control was feasible and efficient	Strict glycemic control
					Minimal risks for hypo- or hyperglycemia
Yuan et al[58] (2015)	Diabetic patients receiving enteral nutrition after gastrectomy	212	None	Strict glycemic control (80-110 mg/dL) and moderate glycemic control (< 200 mg/dL)	Strict glycemic control lead to higher rates of severe hypoglycemia but lower rates of severe hyperglycemia	Strict glycemic control
					Surgical site infection rate was higher with moderate glycemic control
					Rates of other complications were similar in the two groups
Umpierrez et al[59] (2015)	Diabetic patients after coronary artery bypass surgery	152	150 non-diabetics	Strict glycemic control (100-140 mg/dL) and moderate glycemic control (141-180 mg/dL)	No significant differences between the two in the rate and severity of complications	Neither
Kar et al[9] (2016)	Diabetic ICU patients with HbA1c ≥ 7.0% admission	83	None	Moderate glycemic control (< 180 mg/dL) and Loose glycemic control (< 250 mg/dL)	Loose glycemic control reduces glycemic variability and moderate to severe hypoglycemia	Loose glycemic control

ICU: Intensive care unit; HbA1c: Glycosylated hemoglobin.