Management of critically ill patients with diabetes

Table 2 Glycemic control recommendation based on patient condition

Condition	Glucose control recommendation	Studies with patient number	Ref.
Non-diabetic ICU patients	140-180 mg/dL	29 studies with 8432 total patients and 26 studies with 13567 total patients	Wiener et al[30] (2008) and Griesdale et al[31] (2009), respectively
Diabetic ICU patients	If HbA1c < 7%: 140-180 mg/dL	1 retrospective study with 415 total patients	Egi et al[34] (2011)
	If HbA1c > 7%: > 200 mg/dL
Surgical ICU	If ICU stay is for more than 3 d, ventilator dependent, on dialysis, or with cardiac comorbidities: < 150 mg/dL	1 prospective study with 4864 total patients across 17 yr	Furnary et al[40] (2004)
Neurocritical ICU patients	If not: < 180 mg/dL	16 studies with 1258 total patients	Kramer et al[43] (2012)
	If hypoglycemia can be prevented: 110-140 mg/dL
	If not: 140-180 mg/dL
STEMI ICU patients	< 200 mg/dL	No high quality studies available Consensus by NICE	Nice Guidelines[47] (2011)
Sepsis ICU patients	< 180 mg/dL	1 randomized control trial with 6104 patients	Based of NICE-SUGAR study[17]
Pregnant ICU patients	No consensus	N/A	Van de Velde et al[55] (2013)

ICU: Intensive care unit; N/A: Not applicable; HbA1c: Glycosylated hemoglobin; NICE-SUGAR: Normoglycemia in Intensive Care Evaluation-Survival Using Glucose Algorithm Regulation.