Role of angiotensin converting enzyme and angiotensinogen gene polymorphisms in angiotensin converting enzyme inhibitor-mediated antiproteinuric action in type 2 diabetic nephropathy patients

doi:10.4239/wjd.v8.i3.112

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Mar 15, 2017; 8(3): 112-119
Published online Mar 15, 2017. doi: 10.4239/wjd.v8.i3.112

Table 6 Genotypic distribution of responders and non-responders having micro-/ macro-albuminuria

Gene	Genotype (n = 252)	Micro-albuminuric group (n = 170)			Macro-albuminuric group (n = 82)
		R (%) (n = 76)	NR (%) (n = 94)	P-value¹	Rc (%) (n = 45)	NR (%) (n = 37)	P-value²
ACE (I/D)	II	23 (45)	28 (55)	0.974	15 (56)	12 (44)	0.636
	ID	42 (44)	53 (56)		20 (53)	18 (47)
	DD	11 (49)	13 (54)		10 (59)	7 (41)
AGT (M235T)	MM	25 (60)	17 (40)	0.11	9 (47)	10 (53)	0.201
	MT	36 (40)	53 (60)		23 (51)	22 (49)
	TT	15 (38)	24 (62)		13 (72)	5 (28)

¹P > 0.05: Comparison between responders and non-responders to therapy in micro-albuminuric group;

²P > 0.05: Comparison between responders and non-responders to therapy in macro-albuminuric group. ACE: Angiotensin converting enzyme; AGT: Angiotensinogen; R: Responders; NR: Non-responders.

Citation: Aggarwal N, Kare PK, Varshney P, Kalra OP, Madhu SV, Banerjee BD, Yadav A, Raizada A, Tripathi AK. Role of angiotensin converting enzyme and angiotensinogen gene polymorphisms in angiotensin converting enzyme inhibitor-mediated antiproteinuric action in type 2 diabetic nephropathy patients. World J Diabetes 2017; 8(3): 112-119
URL: https://www.wjgnet.com/1948-9358/full/v8/i3/112.htm
DOI: https://dx.doi.org/10.4239/wjd.v8.i3.112