Association of NFKB1 gene polymorphism (rs28362491) with levels of inflammatory biomarkers and susceptibility to diabetic nephropathy in Asian Indians

Table 3 Interaction analysis of -94 ins/del ATTG polymorphism with inflammatory markers

Inflammatory marker	Groups	NG (n = 100)	DM (n = 100)	DM-CRD (n = 100)	P value
uMCP-1 (pg/mg creatinine)	Total	130.00 ± 42.22	271.00 ± 120.01	5632.70 ± 1007.20ab
	del/del	85.1 ± 9.2	200.6 ± 66.5	4609.9 ± 900.6	P = 0.026
	ins/del	110.9 ± 15.6	278.9 ± 105.9	5879.9 ± 1016.3
	ins/ins	166.8 ± 26.8	302.2 ± 100.1	6405.1 ± 1550.6
Plasma TNF-α (pg/mL)	Total	15.55 ± 2.22	16.51 ± 3.75	21.38 ± 3.67ab
	del/del	8.27 ± 1.06	10.21 ± 1.32	17.31 ± 1.17	P = 0.030
	ins/del	11.55 ± 0.05	14.05 ± 0.18	19.31 ± 0.44
	ins/ins	15.08 ± 1.15	16.36 ± 1.20	23.12 ± 0.70

^aSignificantly different from Normoglycemic at P < 0.001;

^bSignificantly different from diabetic patients without nephropathy at P < 0.001. uMCP-1 levels, plasma TNF-α levels are expressed as mean + SD. NG: Normoglycemic; DM: Diabetes mellitus without nephropathy; DM-CRD: Diabetic nephropathy.