Review
Copyright ©The Author(s) 2017.
World J Diabetes. Dec 15, 2017; 8(12): 489-511
Published online Dec 15, 2017. doi: 10.4239/wjd.v8.i12.489
Table 4 Genetic variants studied in relation to gestational diabetes mellitus
GeneLocationVariantAssociation
Genes related to insulin secretion
ABCC811p15.1tagGCC allele of exon 16 and the AGG allele of the R1273RSignificant[97]
KCNJ1111p15.1E23KSignificant[98]
UCP-211q13UCP2-866G> AControversial[98]
MT-ND1mtDNAT3398C mutationSignificant[100]
TCF7L210q25.3rs7903146Significant[101,102]
GCK7p15.3-p15.1rs1799884 (-30G/A)Significant[105-107]
HNF4A20q13.12rs2144908, rs2425637 and rs1885088No association[105]
HNF1A12q24.2rs1169288, rs1800574No association[105,108]
Genes of insulin and insulin receptors
INS11p15.5INS-VNTR class-III alleleControversial[110,111]
INSR19p13.3-p13.2INSR allele-1 Kpn I RFLPSignificant[112]
IGF211p15.5IGF2 Bam HI RFLPSignificant[112]
IGF2BP23q27.2rs4402960Significant[113-115]
IRS12q36rs1801278 (Gly972Arg)Controversial[98,107]
Genes of insulin resistance
PPARG3p25rs1801282No association[107]
PPARGC1A4p15.1rs8192678No association[101,118]
ADRB38p11.23rs4994 (Trp64Arg)Controversial[101,194,119-121]
SLC2A11p34.2SLC2A1 Xba I RFLPNo association[112]
ADIPOQ3q27rs1501299No association[101]
FOXC216q24.1-512C alleleNo association[101]
HLA genes
HLA6p21DR3 and DR4Controversial[122,123,125]
HLA6p21DR3-DQ2/X, DR4-DQ8/X with positive autoantibodiesAssociated[124]
HLA6p21DR7-DQ2/X, DR9-DQ9/X and DR14-DQ5/XAssociated[124]
HLA6p21DQB1 allelesAssociated[111]
Other genes
CAPN102q37.3SNP-19, SNP-43, SNP-44, SNP-63)No association[98,101]
HFE6p21.3C282Y in Northern and Central European womenAssociated[127]
HFE6p21.3H63DNo association[127]
MBL210q11.2rs1800450 (Gly54Asp)Significant[128]
MBL210q11.2rs5030737 (Arg52Cys)No association[128]
SERPINE17q22.1-675 4G/5GCould be associated[130]