Neutral protamine hagedorn/regular insulin in the treatment of inpatient hyperglycemia: Comparison of 3 basal-bolus regimens

Table 4 Rate of hypoglycemia among the study groups during the hospitalization

	NPH × 1, n = 30	NPH × 2, n = 40	NPH × 3, n = 35	P
Hypoglycemic events (n)	13	8	16
Severe hypoglycemia	–	1	–	0.45
Rate of hypoglycemia (%), (X ± SD)1	2.0 ± 3.8	0.7 ± 2.3	1.2 ± 3.1	0.21
Time to the first episode (d), (X ± SD)	6.2 ± 4.0	7.1 ± 1.2	8.2 ± 1.2	0.14
Insulin dose at event (IU/kg), (X ± SD)	0.38 ± 0.13	0.67 ± 0.17	0.94 ± 0.48	< 0.001
Time of presentation, n (%)
Before breakfast	5 (38.5)	2 (25.0)	1 (6.2)	0.11
Before supper	3 (23.1)	3 (37.5)	2 (12.5)	0.37
Before dinner	2 (15.4)	–	7 (43.8)	0.04
Bedtime	3 (23.1)	3 (37.5)	6 (37.5)	0.43

¹Data are expressed as proportion of events/total glucoses.