Neutral protamine hagedorn/regular insulin in the treatment of inpatient hyperglycemia: Comparison of 3 basal-bolus regimens

Table 2 Glycemic control and insulin dose¹

	NPH × 1, n = 30	NPH × 2, n = 40	NPH × 3, n = 35	P
Mean glucose (mg/dL)	160.3 ± 36.4	190.4 ± 48.0	178.7 ± 44.2	0.02
Fasting glucose (mg/dL)	149.2 ± 36.5	175.9 ± 54.6	169.5 ± 43.2	0.054
Random glucose (mg/dL)	164.4 ± 38.2	198.9 ± 53.2	181.0 ± 47.8	0.013
Glycemic control (%)	58.3 ± 25.3	42.4 ± 24.3	48.9 ± 24.1	0.031
Fasting glucose (%)	47.0 ± 35.0	34.0 ± 30.8	42.5 ± 32.3	0.253
Random glucose (%)	62.8 ± 25.9	45.5 ± 25.2	52.8 ± 26.6	0.024
50% daily glucoses within target range (%)	53.0 ± 29.4	43.8 ± 29.5	48.1 ± 30.6	0.455
Time to achieve 50% of daily glucoses within target range (h)	48.9 ± 27.8	61.2 ± 33.9	59.6 ± 47.0	0.438
75% daily glucoses within target range (%)	27.4 ± 26.5	14.3 ± 21.1	21.8 ± 25.5	0.069
Time to achieve 75% of daily glucoses within target range (h)	76.8 ± 48.4	84.8 ± 57.3	99.8 ± 85.1	0.904
Insulin dose (UI/kg)
Basal	0.44 ± 0.13	0.51 ± 0.18	0.52 ± 0.15	0.1
At discharge	0.48 ± 0.14	0.69 ± 0.28	0.65 ± 0.20	< 0.001
Δ Insulin dose	0.04 ± 0.10	0.19 ± 0.22	0.13 ± 0.18	0.004

¹Data are expressed as X ± SD.