Neuroendocrine hormone amylin in diabetes

Figure 1 Overview of physiological actions of amylin. (1) Amylin suppresses glucagon secretion from islet alpha cells at mealtime and thus, inhibits glucagons-induced glucose release from the liver; (2) Amylin delays nutrient delivery from the stomach to the small intestine for absorption; (3) Amylin reduces food intake by a signal mediated through the central nervous system; (4) Renal amylin may stimulate Renin-Angiotensin System; and (5) Amylin and insulin coordinate storage of carbohydrate.