Neuroendocrine hormone amylin in diabetes

doi:10.4239/wjd.v7.i9.189

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. May 10, 2016; 7(9): 189-197
Published online May 10, 2016. doi: 10.4239/wjd.v7.i9.189

Table 1 Physiological actions of amylin

Neuroendocrine effects

Inhibiting insulin secretion in a high concentration

Inhibiting glucagon secretion at mealtime

Delaying nutrient delivery from stomach to the small intestine

Reducing food intake by a signal from the central nervous system

Metabolic effects

Co-regulating glucose with insulin and glucagon

Inhibiting muscle glycogen synthesis[15]

Stimulating oxidative responses and low density lipoprotein uptake in insulin-producing cells

Inhibiting bone resorption

Lipolytic-like effects

Renal effects

Renin ↑

Angiotensin II ↑

Regulating renal growth

Regulating water-sodium homeostasis

Haemodynamic effect

Aldosterone ↑

Hypocalcaemia

Vasodilation

Citation: Zhang XX, Pan YH, Huang YM, Zhao HL. Neuroendocrine hormone amylin in diabetes. World J Diabetes 2016; 7(9): 189-197
URL: https://www.wjgnet.com/1948-9358/full/v7/i9/189.htm
DOI: https://dx.doi.org/10.4239/wjd.v7.i9.189