Use of fibrates in the metabolic syndrome: A review

Table 1 The thresholds defining the metabolic syndrome issued by individual organisations (reproduced from: Strange et al[23])

Group	WHO[24]	EGIR[25]	NCEP/ATP III[27]	AACE[26]	IDF consensus[28]	IDF consensus (10 to < 16 yr)[112]
Definition	IGT, IFG, T2DM or lowered insulin sensitivity plus 2 of the following	Plasma insulin > 75th percentile plus 2 of the following	3 of the following	IGT or IFG plus any of the following based on clinical judgement	See below
Europoid waist circumference (cm)	W:H > 0.90 M, W:H > 0.85 F or BMI > 30 kg/m2	≥ 94 M, ≥ 80 F	≥ 102 M, ≥ 88 F	BMI ≥ 25 kg/m2	≥ 94 M, ≥ 80 F or BMI > 30 kg/m2 plus 2 of the following	> 90th percentile plus 2 of the following
Triglyceride (mmol/L)	> 1.7	> 1.7	≥ 1.7	> 1.7	> 1.7	≥ 1.7
HDL (mmol/L)	< 0.91 M, < 1.01 F	< 0.91	< 1.03 M, < 1.29 F	< 1.03 M, < 1.29 F	< 1.03 M, < 1.29 F	< 1.03
BP (mmHg)	≥ 140/90	≥ 140/90 or on treatment	≥ 130/85	≥ 130/85	SBP ≥ 130 or DBP ≥ 85 or on treatment	SBP ≥ 130 and/or DBP ≥ 85
Glucose (mmol/L)	IGT, IFG or T2DM	IGT or IFG (but not diabetes)	≥ 5.6[113] or diabetes	IGT or IFG (but not diabetes)	≥ 5.6	≥ 5.6 or known T2DM
Others	Microalbuminuria ACR > 30 mg/g			Other features of IR1

¹Includes polycystic ovary syndrome, family history or ethnic group susceptible to type 2 diabetes, sedentary lifestyle and advancing age. ACR: Albumin creatinine ration; BMI: Body mass index; DBP: Diastolic blood pressure; F: Female; IFG: Impaired fasting glucose; IGT: Impaired glucose tolerance; IR: Insulin resistance; SBP: Systolic blood pressure; M: Male; T2DM: Type 2 diabetes mellitus; W:H: Waist to hip ratio; HDL: High density lipoprotein; WHO: World Health Organisation; NCEP: National cholesterol education program; EGIR: European group for the study of insulin resistance; IDF: International diabetes federation; AACE: American Association of Clinical Endocrinologists.