Glucagon-like peptide 1 in the pathophysiology and pharmacotherapy of clinical obesity

Table 2 Obesity and endocrine phenotypes in probands with PCSK1 gene deletion monogenic obesity

Ref.	Jackson et al[144], 1997	Jackson et al[143], 2003	Farooqi et al[148], 2007	Frank et al[145], 2013	Parker et al[147], 2013	Bandsma et al[146], 2013
Obesity phenotype
Hyperphagic, early-onset	Yes	Yes	Yes	Yes	Yes	Yes
Endocrine phenotype
Abnormal glucose metabolism	Yes	Yes		Yes	Yes	Yes
Hypogonadotrophic hypogonadism	Yes			Yes	Yes
Hypocortisolaemia	Yes	Yes		Yes	Yes
Hypothyroidism			Yes	Yes	Yes
Central diabetes insipidus					Yes
Others
Early onset malabsorptive diarrhoea	Yes	Yes	Yes	Yes	Yes	Yes

Proband details: Jackson et al[144] (1997) - a 40-year-old Caucasian woman; Jackson et al[143] (2003) - female Caucasian infant, non consanguineous; Farooqi et al[148] (2007) - 6 North African boy, consanguineous; Frank et al[145] (2013) - male infant; Parker et al[147] (2013) - 13 children aged 3 to 17; Bandsma et al[146] (2013) - 2 children age 2 and 7 Arab, consanguineous, 2 children aged 1 and 10, African, non-consanguineous.