Linagliptin alleviates fatty liver disease in diabetic db/db mice

Figure 9 Ultrastructural changes in the hepatocytes of intact db/db mice. A: Fields of “foamy” hyperplastic smooth ER and fields of glycogen, lipid inclusions in the cytoplasm of hepatocytes; B and E: Pronounced exocytosis of vacuoles with lipid content into the Disse space (arrows); C and D: Pronounced exocytosis of vacuoles with lipid content into gaps between hepatocytes (arrows); F: The bile capillary (white arrow) and compartments of the mito-ER-complexes (complexes from ER and mitochondria), active Golgi complexes, residual bodies and autophagosomes (black arrow) at the biliary poles of hepatocytes. V: Microvilli on the lateral surface of hepatocytes; L: Lipid inclusions; m: Mitochondria; e: Erythrocyte; EPR: Endoplasmic reticulum.