Implanting 1.1B4 human β-cell pseudoislets improves glycaemic control in diabetic severe combined immune deficient mice

Figure 2 Effects on food and fluid intake, body weight and blood glucose of streptozotocin diabetic severe combined immunodeficient mice implanted with 1. 1B4 cells/ pseudoislets. A: Food intake; B: Fluid intake; C: Change in body weight; D: Blood glucose. From day 6-27, all diabetic mice were injected with insulin (15 U/kg bw) every 8 h (Indicated by black bar). At the end of the study, glucose tolerance (E) was determined over a time course of 120 min. Values are mean ± SEM (n = 4). ^aP < 0.05, ^dP < 0.01 and ^fP < 0.001 vs diabetic control animals; ^gP < 0.05, ^jP < 0.01 vs 1.1B4 cell suspension recipients.