Diabetes therapies in hemodialysis patients: Dipeptidase-4 inhibitors

Table 2 Combinations of oral antidiabetic drugs with dipeptidase-4 inhibitors

Class	Action mechanism	Glucose target	Drug	Daily dose (mg)
Sulfonylurea	Increases insulin secretion	Fasting and postprandial	Glipizide	2.5-10
			Gliclazide	40-240
			Gliquidone	45-60
Meglitinide	Increases insulin secretion	Postprandial	Repaglinide	0.5-12
			Mitiglinide	7.5-15
Thiazolidinediones	Insulin sensitizer	Fasting and postprandial	Rosiglitazone	4-8
			Pioglitazone	15-45
Alpha-glucosidase inhibitor	Delays carbohydrate absorption	Postprandial	Voglibose	0.6-0.9
			Acarbose	75-300
			Miglitol	150-225