Recent progress in the genetics of diabetic microvascular complications

Figure 2 Possible molecular mechanisms. Possible molecular mechanisms by which ELMO1 (A), IRS2 (B), and MYH9 (C) regulate diabetic nephropathy. TRIO: Triple functional domain (PTPRF interacting); RhoG: Ras homolog family member G; GDP: Guanosine diphosphate; GTP: Guanosine triphosphate; MMP: Matrix metalloproteinases; Crk II: V-Crk Avian Sarcoma Virus CT10 Oncogene Homolog II; TGF-β: Transforming growth factor beta; AKT: Protein kinase B; mLSTS: Mammalian lethal with SEC13 protein 8; mTOR: Mammalian target of rapamycin; mTORC2: Mammalian target of rapamycin complex 2; mSin1: Mammalian SAPK interacting protein; PKC: Protein kinase C; SGK1: Serum- and glucocorticoid-induced kinase 1.