Review
Copyright ©The Author(s) 2015.
World J Diabetes. Jun 10, 2015; 6(5): 693-706
Published online Jun 10, 2015. doi: 10.4239/wjd.v6.i5.693
Table 7 Observational studies and outcomes related to hypoglycaemia (chronological order)
Ref.YearStudy ptsStudy pointNon diabetic patientsDiabetic patientsOverall message
Krinsley and Grover[60]2007408Risk factors for developing hypoglycaemia in ICU and outcomesSevere hypoglycaemia associated with septic shock. Renal insufficiency, mechanical ventilation, illness severity and use of ITTAssociated with inc risk of severe hypoglycaemia (P < 0.01)DM had no association with mortalityMortality in severe hypoglycaemia cohort 56% vs control cohort 40%, P < 0.01
Egi et al[61]20104946Hypoglycaemia vs risk of death in critically ill patientsMild or moderate hypoglycaemia was associated with mortality in critically ill patientsMortality increases as severity of hypoglycaemia increasesDiabetic patients more likely to suffer from insulin-associated hypoglycaemia22% of total patients had one episode of hypoglycaemiaHospital mortality: hypoglycaemic cohort 37% vs control cohort 20%, P < 0.01
Krinsely et al[33]201162401Mild hypoglycaemia (blood glucose level < 3.9 mmol/L) vs risk of mortality in critically ill patients.Mild hypoglycaemia was associated with a significantly increased risk of mortalityThe association between hypoglycaemia and mortality was independent of diabetic statusInc severity of hypoglycaemia was associated with inc risk of mortalityHypoglycemic patients had higher mortality regardless of diagnostic category and ICU LOS
Krinsley et al[32]201344964Hyperglycaemia, hypoglycaemia, and glycemic variability vs mortality (and how DM effects this)Inc mortality with higher mean blood glucose (≥ 7.8 mmol/L)Dec mortality with lower blood glucose (4.4-7.8 mmol/L)Inc mortality with mean blood glucose between 4.4-6.1 mmol/LDec mortality when blood glucose were higher (6.2-10 mmol/L)Hyperglycaemia, hypoglycaemia, and increased glycemic variability are independently associated with mortality in ICU patientsDiabetic status tempers these relations