Copyright
©The Author(s) 2015.
World J Diabetes. May 15, 2015; 6(4): 598-612
Published online May 15, 2015. doi: 10.4239/wjd.v6.i4.598
Published online May 15, 2015. doi: 10.4239/wjd.v6.i4.598
Figure 5 Activation of inflammasomes in type 2 diabetes (metabolic stress activates multiprotein complex, inflammasome in β-cells that induce caspase-1 to cleave pro-interleukin-1β (pro-IL-1β) into active IL-1β.
β-cell-derived IL-1β promote the release of chemokines and recruitment of macrophages that are activated by human islet amyloid polypeptide, leading to deleterious concentrations of IL-1β. FFA: Free fatty acid; IL: Interleukin.
- Citation: Hameed I, Masoodi SR, Mir SA, Nabi M, Ghazanfar K, Ganai BA. Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition. World J Diabetes 2015; 6(4): 598-612
- URL: https://www.wjgnet.com/1948-9358/full/v6/i4/598.htm
- DOI: https://dx.doi.org/10.4239/wjd.v6.i4.598