Adipose tissue fibrosis

Figure 2 Mice with leptin deficiency (ob/ob mice) have large adipocytes and their size further increases when collagen 6 (COL6KOob/ob) is knocked-out in these animals. Weakening of the extracellular matrix is associated with improved adipose tissue insulin response, reduced inflammation and TGF-beta signaling, and diminished adipocyte necrosis. Subsequently metabolic situation is improved.