Effects of exercise on brain functions in diabetic animal models

Table 2 Summary of animal model of Type 2 diabetes mellitus

Induction	Model	Main characteristics	Model uses
Obese models	ob/ob mice db/db mice KK mice KK/Ay mice NZO mice TSOD mice Zucker fatty rat Zucker diabetic fatty rat OLETE rat	Obesity-induced hyperglycemia	Identifying factors involved in obesity-induced diabetes Some models show diabetic complications Treatments to improve beta cell function
Non-obese models	GK rat Cohen diabetic rat	Hyperglycemia induced by insufficient beta cell function	Treatments to improve beta cell function and beta cell survival
Diet/nutrition induced obesity	High fat feeding (mice and rat) Desert gerbil Nile grass rat	Obesity-induced hyperglycemia	Treatments to improve insulin resistance Treatments to improve beta cell function Treatments to prevent diet-induced obesity
Surgical diabetic animals	VMH lesioned dietary Obese diabetic rat Partially pancreatectomized animals (dog, primate, pig and rats)	Avoid cytotoxic effects of chemical diabetogens on other body organs Resembles human T2DM due to reduced pancreatic islet beta cell mass	Occurrence of hyperphagia Pancreatitis
Transgenic/knock-out diabetic animals	Uncoupling protein (UCP1) Knock out mice HiAPP mice	Poor activation of thermogenesis Amyloid deposition in islets	Treatments of obese conditions Increase obesity (energy storage) Treatments to prevent amyloid deposition