New-onset diabetes mellitus after kidney transplantation: Current status and future directions

Table 2 Potential pathogenic mechanisms for drug-induced new-onset diabetes mellitus after transplantation

Immunosuppressive drug	Mechanism for new-onset diabetes after transplantation
Corticosteroids	Increased gluconeogenesis Increased insulin resistance Reduced glycogenesis Decreased insulin release Impaired pancreatic beta cell function
Calcineurin-inhibitors (cyclosporine, tacrolimus)	Reduced glucose uptake Decreased insulin release Reduced insulin gene expression Direct pancreatic beta cell toxicity
Sirolimus	Hypertriglyceridemia ? Decreased pancreatic beta cell proliferation

?: Requires further investigation.