Association of gene variants with susceptibility to type 2 diabetes among Omanis

Table 2 Risk allele frequencies for the tested gene variants among Omani type 2 diabetes mellitus patients and control participants

Gene	Gene variant	Risk/non-	Risk allele frequency (f)		1P value	OR	95%CI
	(SNPs)	risk allele	T2D patients (n = 992)	Controls (n = 294)			for OR
KCNJ11	rs5219	T/C	0.320	0.222	25.8 × 10-6	1.74	1.37-2.22
TCF7L2	rs7903146	T/C	0.445	0.354	20.001	1.46	1.16-1.83
CDKAL1	rs10946398	C/A	0.364	0.311	20.002	1.44	1.15-1.80
CDKN2A/B	rs10811661	T/C	0.836	0.799	0.020	1.40	1.06-1.84
FTO	rs9939609	A/T	0.480	0.435	0.358	1.11	0.899-1.37
FTO	rs8050136	A/C	0.458	0.425	0.770	1.03	0.829-1.29
IGF2BP2	rs4402960	T/G	0.400	0.357	0.286	1.13	0.904-1.41
SLC30A8	rs13266634	C/T	0.857	0.855	0.329	1.16	0.859-1.57
CAPN10	rs3792267 (-43)	G/A	0.802	0.790	0.445	1.11	0.850-1.45
HHEX	rs1111875	T/C	0.301	0.280	0.636	1.06	0.839-1.33

¹P value: Level of significance;

²P value remained significant after correction for multiple testing (< 0.005). The P value, OR and 95%CI were calculated for the association between each gene variant with T2D risk. f: Frequency; T2D: Type 2 diabetes mellitus; SNPs: Single nucleotide polymorphisms.