Copyright
©The Author(s) 2015.
World J Diabetes. Mar 15, 2015; 6(2): 345-351
Published online Mar 15, 2015. doi: 10.4239/wjd.v6.i2.345
Published online Mar 15, 2015. doi: 10.4239/wjd.v6.i2.345
Table 3 Studies on the role of tight glycemic control in long-standing diabetes mellitus
| Study | No. participants | Years since diagnosis | Mean age at enrollment (yr) | Length of follow up (yr) | Population | Results |
| ACCORD trial[32] | 10251 | 10 (median) | 62.2 ± 6.8 | 3.4 (median) | United States and Canada | Terminated after 3.5 yr; excessive deaths in the intensive glycemic control arm |
| ADVANCE trial[33] | 11140 | 8 (mean) | 66 ± 6 | 5 (median) | Asia, Australasia, Europe, and North America (20 countries) | No significant effect of tight glycemic control on major macrovascular events or death; significant reduction in nephropathy incidence |
| VADT trial[34] | 1791 | 11.5 (mean) | 60.5 ± 9 | 5.6 (median) | United States military veterans; 97% males | No significant effect of tight glycemic control on major macrovascular events or death |
| Diabetes and aging study[36] | 71092 | 8.3 (mean) | 71 ± 7.4 | 3.1 (mean) | California, United States | U-shape relationship between mortality and HbA1c, with the lowest mortality rate at HbA1c 6%-8% |
- Citation: Twito O, Frankel M, Nabriski D. Impact of glucose level on morbidity and mortality in elderly with diabetes and pre-diabetes. World J Diabetes 2015; 6(2): 345-351
- URL: https://www.wjgnet.com/1948-9358/full/v6/i2/345.htm
- DOI: https://dx.doi.org/10.4239/wjd.v6.i2.345