Simvastatin, atorvastatin, and pravastatin equally improve the hemodynamic status of diabetic rats

Table 4 Effect of chronic statin treatment on EC₅₀ and E_MAX values following ach-induced relaxation in diabetic and control rats

Condition	Emax relaxation, %	EC50, μmol/L
CT none	74.61 ± 3.27	0.56 ± 0.11
CT + AV	70.75 ± 3.99	0.68 ± 0.22
CT + SV	70.76 ± 4.16	1.15 ± 0.47
CT + PV	71.16 ± 4.30	0.72 ± 0.20
Diabetic none	53.70 ± 4.07a	0.41 ± 0.10
Diabetic + AV	82.13 ± 7.01c	0.84 ± 0.32
Diabetic + SV	84.63 ± 6.51c	0.40 ± 0.21
Diabetic + PV	83.88 ± 6.83c	0.66 ± 0.35

Values shown are the means ± SEM of an average of 10 animals per group.

^aP < 0.05 when vs age-matched treated and untreated CT;

^cP < 0.05 when vs age-matched untreated diabetic rats. No statistically significant differences were found between treated diabetic rats and treated CT. AV: Atorvastatin; SV: Simvastatin; PV: Pravastatin; CT: Control.