Nonalcoholic steatohepatitis and insulin resistance in children

Table 1 Differences in characteristics of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis between adults and children

	Pediatric-type NASH	Adult-type NASH
Classification by Schwimmer et al[21]	Type 2	Type 1
Incidence	Frequent	Rare
Steatosis	Strong	Weak
	Starting in periportal zone (acinar zone 1)	Starting in perivenular zone (acinar zone 3)
Inflammatory cell infiltration	Portal area	Centrolobular area
Hepatocyte ballooning	None	Prevalent
Fibrosis	None or only in periportal zone (acinar zone 1)	Prevalent in perisinusoidal or perivenular zone (acinar zone 3)
Liver cirrhosis	Present	Present
Epidemiology	More common in overweight, colored race (Hispanic: 73%; Asian: 12%), boys > girls	Hispanic: 41%, White, non-Hispanic: 53%, girls > boys
Ratio in pediatric NAFLD (overlap 16%) by Schwimmer et al[21]	51%	17%
Ratio in pediatric NAFLD (overlap 50%) by Takahashi et al[20]	21%	Not reported

NASH: Nonalcoholic steatohepatitis; NAFLD: Nonalcoholic fatty liver disease.