Risks of rapid decline renal function in patients with type 2 diabetes

Table 2 Decline of estimated glomerular filtration rate in different populations

Population	eGFR decline (mL/min per 1.73 m2 per year)	Ref.
Healthy
PREVEND study 6894 subjects	0.55	Halbesma et al[5]
	Estimated using MDRD formula
Annual health exam, Japan	0.36	Imai et al[19]
120727 subjects	Estimated using MDRD formula modified by a Japanese coefficient
ARIC study	0.47	Matsushita et al[20]
13029 subjects	Estimated using MDRD formula
Tromso Study, Norway	1.21 (men)	Kronborg et al[21]
2249 men and 2192 women	1.19 (women) Estimated using MDRD formula
Aged without diabetes
2475 men > 65 years old	1.4	Hemmelgarn et al[22]
3163 women > 65 years old	0.8	Hemmelgarn et al[22]
Aged with diabetes
490 men > 65 years old	2.7	Hemmelgarn et al[22]
445 women > 65 years old	2.1	Hemmelgarn et al[22]
CKD
MDRD study group	3.7	MDRD study group
eGFR 25-80 mL/min per 1.73 m2, n = 28		Levey et al[23]
eGFR 7.5-24 mL/min per 1.73 m2, n = 63	4.3
African Americans with hypertension eGFR 20-65 mL/min per 1.73 m2 low mean arterial pressure, n = 380	2.21	Wright et al[24]
normal mean arterial pressure, n = 374	1.95
Tromso Study, Norway	1.03	Eriksen et al[25]
eGFR 30-59 mL/min per 1.73 m2 3047 subjects
eGFR < 60 mL/min per 1.73 m2 4231 subjects	2.65	Levin et al[26]

Data from Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group[18]; eGFR: Estimated glomerular filtration rate; CKD: Chronic kidney disease; PREVEND: Prevention of Renal and Vascular End-Stage Disease; ARIC: Atherosclerosis Risk in Communities; MDRD: Modification of Diet in Renal Disease Study.