Type 2 diabetes and cardiovascular disease: Have all risk factors the same strength?

Figure 2 Prothrombotic mechanisms in diabetes mellitus. The hypercoagulable state related with diabetes mellitus is consequent to improved thrombin generation by platelets, impaired fibrinolysis due to increased levels of plasminogen activator inhibitor type 1 (PAI-1), and low-grade inflammation, that rise circulating levels of interleukin-6 (IL-6), fibrinogen, and tissue factor expression in vascular cells. DM: Diabetes mellitus; IR: Insulin resistance.