Genetic polymorphisms of cytokine genes in type 2 diabetes mellitus

Table 6 Variants of adiponectin gene and their association with type 2 diabetes and related complications in different populations

Gene variants (SNPs)	Diseases	Population- Ethnic groups	Association	Ref.
+45 G/T	Obesity	Iranians	NS	[146]
	T2DM	Malaysian	S	[147]
	T2DM	Greek	NS	[148]
	MS	Chinese	S	[149]
	T2DM	Japanese	NS	[150]
	T2DM	Chinese	S	[151]
	Non-T2DM	Caucasian Canadians	NS	[152]
	T2DM	Hispanic Americans	NS	[153]
	T2DM	French Caucasian	NS	[154]
	T2DM	Korean	NS	[155]
	T2DM	Caucasians	S	[154]
	T2DM	Spanish	NS	[156]
	IGT	European/Canadian	NS	[157]
	Non-T2DM	Japanese	NS	[158]
	Obesity	Swedish	NS	[159]
	T2DM	Caucasian Italians	NS	[160]
	T2DM	Caucasian Italians	NS	[161]
	T2DM	Pima Indians	NS	[162]
	T2DM	European Caucasians	NS	[163]
	T2DM	French Caucasians	S	[164]
+10211 T/G	T2DM	Asian Indians	S	[165]

S: Significant; NS: Non-significant; T2DM: Type 2 diabetes; SNPs: Single nucleotide polymorphisms; MS: Metabolic syndrome; IGT: Impaired glucose tolerance.