Genetic polymorphisms of cytokine genes in type 2 diabetes mellitus

Table 4 Variants of interleukin-10 gene and their association with type 2 diabetes and related complications in different populations

Gene variants (SNPs)	Diseases	Population- Ethnic groups	Association	Ref.
-592 A/C	T2DM	Iranian	NS	[108]
	T2DM	Chinese	NS	[109]
	T2DM	North Indian	S	[4]
-1082 G/A	proliferative diabetic retinopathy	Indian	S	[110]
	T2DM	South Indian	S	[111]
-1082 G/A -819 C/T -592 C/A	T2DM	Caucasian Italian	S	[112]
-1082 G/A	T2DM	Turkish	NS	[113]
-1082 G/A -819 C/T -592 C/A	T2DM	Greek	NS	[106]
-592 A/C -819 C/T	T2DM	Taiwanese	NS	[107]
-592 A/C	T2DM	Taiwanese	S	[114]
-1087 G/A -824 C/T -597 C/A	T2DM	Italian	S	[115]
-592 A/C	T2DM	Tunisian	S	[18]

S: Significant; NS: Non-significant; T2DM: Type 2 diabetes; SNPs: Single nucleotide polymorphisms.