Expression quantitative trait analyses to identify causal genetic variants for type 2 diabetes susceptibility

Table 1 Selected expression quantitative trait loci databases

Database	Website (URL)	Cell/tissue type	Project
eQTL Browser	http://eqtl.uchicago.edu/cgi-bin/gbrowse/eqtl/	LCL, liver, brain, fibroblast, T-cell	17 projects
Genvar	http://www.sanger.ac.uk/resources/software/genevar/	Adipose, LCL Skin fibroblast from healthy female twins	MuTHER
		LCL from 8 populations	Hapamap3
		Fibroblast, LCL and T-cell from umbilical cord	GenCord
GTEx eQTL Browser	http://www.ncbi.nlm.nih.gov/gtex/GTEX2/gtex.cgi	Multiple tissues including liver, brain regions, LCL	GTEx
PACdb	http://www.pacdb.org/	Gene-drug or GXD eSNPs from LCL model	Dolan and Cox lab Lusis lab
SGR Database	http://systems.genetics.ucla.edu/	22 mouse and several human datasets.
		Data includes aortic endothelial and smooth muscle, adipose, brain, liver, macrophages and muscle tissue
		Includes GXE eSNP data from cell experiments
SCAN	http://www.scandb.org/newinterface/about.html	CEU and YRI LCLs from HapMap	Cox Lab
seeQTL	http://www.bios.unc.edu/research/genomic_software/seeQTL/	HapMap LCLs

SGR: Systems genetics resource; eQTL: Expression quantitative trait loci; T2D: Type 2 diabetes; eSNP: Expression regulatory SNP; LCL: Lymphoblastoid cell lines; GXD: Gene-by-drug interaction; GXE: Gene-by-environment interaction; CEU: HapMap caucasian from CEPH collection; YRI: HapMap African from Yuroba, Nigeria.