Down-regulation of pancreatic transcription factors and incretin receptors in type 2 diabetes

doi:10.4239/wjd.v4.i6.263

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Dec 15, 2013 (publication date) through Dec 27, 2024

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Dec 15, 2013; 4(6): 263-269
Published online Dec 15, 2013. doi: 10.4239/wjd.v4.i6.263

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Figure 4 Down-regulation of incretin receptors in pancreatic β-cells under diabetic conditions. Under diabetic conditions, expression of incretin receptors (GLP-1 and GIP receptors) in β-cells are down-regulated, leading to decrease of insulin secretion, increase of β-cell apoptosis and decrease of β-cell growth.

Citation: Kaneto H, Matsuoka TA. Down-regulation of pancreatic transcription factors and incretin receptors in type 2 diabetes. World J Diabetes 2013; 4(6): 263-269
URL: https://www.wjgnet.com/1948-9358/full/v4/i6/263.htm
DOI: https://dx.doi.org/10.4239/wjd.v4.i6.263