High adiponectin levels fail to protect against the risk of hypertension and, in women, against coronary disease: involvement in autoimmunity?

Table 3 Cox regression analyses of serum adiponectin tertiles for incident diabetes, coronary heart disease and hypertension, adjusted for sex, age and relevant confounders

	Total HR	95%CI	Men HR	95%CI	Women HR	95%CI
Diabetes	40/7612		21/3332		19/4282
Adiponectin mid-tertile	0.64	0.32-1.31	0.83	0.30-2.28	0.35	0.11-1.09
Adiponectin top-tertile	0.26	0.10-0.69	0.28	0.07-1.17	0.23	0.06-0.88
Fasting glucose (25 mg/dL)	1.60	1.22-2.04	1.49	1.08-2.09	2.25	1.35-3.72
Waist circumference (12 cm)	1.88	1.43-2.46	2.04	1.44-2.88	1.78	1.13-2.78
Creatinine (0.25 mg/dL)	1.08	0.74-1.58	0.77	0.37-1.60	1.18	0.87-1.60
C-reactive protein1, 3-fold	1.21	0.97-1.52	1.10	0.80-1.51	1.36	0.96-1.73
Coronary disease	66/8052		25/3582		41/4472
Adiponectin mid-tertile	0.54	0.30-0.97	0.8	0.34-1.92	0.39	0.17-0.90
Adiponectin top-tertile	0.49	0.26-0.91	0.31	0.09-1.05	0.66	0.32-1.38
Non-HDL cholester. (35 mg/dL)	1.07	0.87-1.28	1.37	0.97-1.93	0.93	0.70-1.19
Waist circumference (12 cm)	1.46	1.18-1.82	1.28	0.89-1.84	1.60	1.22-2.08
Creatinine (0.25 mg/dL)	1.20	0.91-1.58	1.36	0.85-2.17	1.05	0.69-1.60
C-reactive protein1, (3-fold)	1.12	0.95-1.32	1.06	0.81-1.39	1.18	0.95-1.47
Hypertension	120/5412		53/2742		67/2672
Adiponectin mid-tertile	1.08	0.71-1.91	1.23	0.62-2.43	1.03	0.56-1.89
Adiponectin top-tertile	0.77	0.55-1.59	1.08	0.51-2.30	0.64	0.33-1.24
Waist circumference (12 cm)	1.41	1.14-1.74	1.28	0.93-1.76	1.53	1.14-2.06
Creatinine (0.25 mg/dL)	1.06	0.82-1.37	1.15	0.80-1.66	1.08	0.74-1.59
C-reactive. protein1, 3-fold	0.96	0.85-1.09	1.08	0.90-1.30	0.90	0.76-1.06

¹Log-transformed. All models were additionally sex- and age-adjusted. Referent low adiponectin tertile (< 6.9 men and < 8.8 μg/mL women).

²Number of incident cases/number at risk. Mean creatinine values at baseline were 0.994 in men and 0.776 mg/dL in women, and ages 53.5 and 53 years, respectively.