High adiponectin levels fail to protect against the risk of hypertension and, in women, against coronary disease: involvement in autoimmunity?

Table 2 Linear regression analysis for serum adiponectin

	Total		Men		Women			Total		Men		Women
	βcoeff.	P value	βcoeff	P value	βcoeff	P value		βcoeff	P value	βcoeff	P value	βcoeff	P value
Model 1	n = 513		n = 252		n = 261		Model 2	n = 454		n = 223		n = 231
Sex (female)	1.20	< 0.001					Sex (female)	1.285	< 0.001
Age (11 yr)	1.05	0.055	1.10	0.005	0.997	0.93	Age (11 yr)	1.04	0.13	1.067	0.079	1.007	0.88
Fasting insulin1	0.79	0.009	0.80	0.016	0.79	0.033	C-reactive protein1	0.90	0.057	0.83	0.011	0.98	0.80
SHBG1 (nmol/L)	2.14	< 0.001	1.76	0.001	2.02	< 0.001	SHBG1	1.97	< 0.001	1.77	0.002	2.08	< 0.001
Creatinine (0.25 mg/dL)	1.04	0.67	0.992	0.82	1.085	0.052	Fasting insulin1	0.84	0.026	0.83	0.06	0.86	0.20
							Creatinine (0.25 mg/dL)	1.04	0.14	1.01	0.78	1.081	0.086
							Waist circumference (12 cm)	1.023	0.41	1.021	0.57	1.025	0.52
							Lipoprotein(a)1	1.003	0.94	1.07	0.38	0.96	0.60

All models were significant (P < 0.001), explained 16%/17% of adiponectin variance in genders combined, 14%/16% in men and 12% in women.

¹Log-transformed values. SHBG: Sex hormone-binding globulin.