High adiponectin levels fail to protect against the risk of hypertension and, in women, against coronary disease: involvement in autoimmunity?

Table 1 Characteristics of sample (n = 1224) by gender and serum adiponectin (in μg/mL) tertiles

n		Men (n = 561)							Women (n = 663)
		1 4.941		2 8.50		3 15.36		AnovaP-trend	1 6.121		2 10.87		3 19.67		AnovaP-trend
		Mean	SD	Mean	SD	Mean	SD		Mean	SD	Mean	SD	Mean	SD
Age (yr)	1224	52.2	10.1	53.8	11	58.14	11.9	< 0.001	52.8	10.3	53.5	11.9	57.14	12	< 0.001
BMI (kg/m2)	1213	28.2	4	29.3	4.3	27.3	4.5	0.23	31.84	6	30.3	4.8	30.1	5.7	0.003
Waist circumfer. (cm)	1217	97.3	11.1	96.8	10.6	95	11.9	0.11	94.3	12.7	92.1	11.4	91.2	12.7	0.024
Systolic BP (mmHg)	1217	120.6	18.8	121.3	19.6	121.8	20.3	0.83	130.5	23.9	126.4	21.7	127.3	23.7	0.15
Diastolic BP (mmHg)	1217	77.8	10.8	77.7	10.3	77.6	10.6	0.98	80.8	11.5	79.7	10.4	80	11.8	0.54
Complement C3 (g/L)	610	1.36	0.27	1.29	0.27	1.23	0.27	0.007	1.44	0.29	1.37	0.33	1.24	0.24	< 0.001
CRP3 (mg/L)	1143	2.26	1.25-5.06	2.11	1.02-3.9	1.424	0.76-3.2	< 0.001	2.72	1.15-6.33	2.61	1.21-6.18	2.29	1.08-4.0	0.025
Total cholest. (mg/dL)	1213	191.3	40	194.8	38	190	40.3	0.46	201	41.7	205.4	53	204.9	44.3	0.54
Fast. glucose, (mg/dL)	1124	99	39	99.6	37.8	94	25.8	0.27	101.9	43.9	99	38.2	93.7	32	0.093
ApoB (mg/dL)	1116	107.6	26.7	105.3	28.9	100.4	46.9	0.15	106	26.3	104.3	32.5	106.9	37.5	0.72
Creatinine (mg/dL)	1144	1.02	0.19	1.02	0.22	0.99	0.22	0.24	0.78	0.21	0.79	0.18	0.84	0.42	0.066
Fast. triglycer.3 (mg/dL)	1123	160.84	108-227	138.1	100-187	126.2	89-174	< 0.001	146.2	108-206	133.5	99.9-182	1174	83.5-164	< 0.001
HDL-cholest. (mg/dL)	1207	35.6	8.3	39.5	9.8	434	11.3	< 0.001	43.9	11.5	45.6	10.6	49.44	11.7	< 0.001
Apo A-I (mg/dL)	1103	129.7	25	134.7	25.1	138.9	25.8	0.004	144.3	26.4	145.7	29.9	152.6	28.1	0.008
Lp (a)3 (mg/dL)	764	8.16	3.8-18.2	7.93	3.2-19.4	9.36	3.4-20.6	0.52	12.1	5.3-24.5	13.3	5.7-23.6	12.4	4-29.4	0.85
Thyroid SH3 (mIU/L)	532	1.06	0.7-1.6	1.05	0.6-1.7	1.01	0.67-1.5	0.89	1.53	0.97-2.45	1.47	0.84-2.3	1.37	1.0-2.46	0.70
Current/former smok (%)	1218	58.4	20	47.9	21.1	45.9	29	0.035	16	3.7	18.6	3.6	14.7	3.7	0.87
Prevalent diabetes2 (%)	1219	11.8		12.6		13.1		0.93	17.7		12.1		12.9		0.18
Incident CHD, n (%)	1061	13 (8.2)		11 (6.7)		4 (2.5)		0.086	21 (11.1)		8; 4		16 (8.4)		0.029

¹Geometric mean adiponectin value of the tertile;

²Excluded from the study;

³Median and interquartile range;

⁴Values differing from both of the other tertiles. CRP: C-reactive protein; BMI: Body mass index; BP: Blood pressure; CHD: Coronary heart disease; HDL: High-density lipoprotein; LP: Lipoprotein.