Diabetes-related impairment in bone strength is established early in the life course

Figure 3 Tibia strength by 3-point breakage analysis using the NTS 85MTS Minibionix8 with a 100 N load cell. The span was 9 mm and the bones were loaded with a rate of 0.1 mm/s to evaluate maximum load to failure in 5 and 8 wk in non-obese diabetic (dark gray bars) and syngenic non-diabetic (light gray bars). Error bars represent SEM. ^aNon-obese diabetic mice demonstrated less mechanical strength than syngenic non-diabetic mice at 5 wk.