Diabetes-related impairment in bone strength is established early in the life course

doi:10.4239/wjd.v4.i4.145

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Aug 15, 2013; 4(4): 145-150
Published online Aug 15, 2013. doi: 10.4239/wjd.v4.i4.145

Table 2 Presents the bone quality measures using micro computed tomography assessed at 5 and 8 wk

	5 wk		8 wk
	NOD(n = 4)	NOD.scid(n = 4)	NOD(n = 6)	NOD.scid(n = 4)
Body weight	14.9 ± 0.2	19.2 ± 0.4¹	19.2 ± 0.5	19.9 ± 0.6
BMC	0.19 ± 0.01	0.30 ± 0.01¹	0.30 ± 0.02	0.30 ± 0.01
BMD	0.030 ± 0.001	0.040 ± 0 .002	0.040 ± 0.001	0.040 ± 0.001
Tibia strength	4.5 ± 0.2	10.0 ± 0.8	8.4 ± 0.7	8.2 ± 0.8
Trabecular bone properties
TV	1.4 ± 0.2	1.6 ± 0.1	1.50 ± 0.06	1.40 ± 0.04
BV	0.08 ± 0.02	0.14 ± 0.01	0.11 ± 0.02	0.16 ± 0.05
BV/TV	0.05 ± 0.02¹	0.09 ± 0.00	0.07 ± 0.01	0.11 ± 0.04¹
Tb. Tk	0.05 ± 0.01	0.05 ± 0.00	0.05 ± 0.00	0.05 ± 0.01
Tb. N	2.0 ± 0.3¹	2.8 ± 0.3	2.40 ± 0.09	2.90 ± 0.58
Tb. TMV	63.8 ± 4.9	108.9 ± 7.4¹	104.3 ± 8.9	137.0 ± 14.6
Tb. TMD	872.7 ± 42.5	930.5 ± 17.6	891.8 ± 21.3	948.8 ± 65.2
Cortical bone properties
TV	0.18 ± 0.02¹	0.23 ± 0.02	0.20 ± 0.02	0.20 ± 0.02
BV	0.10 ± 0.02	0.14 ± 0.02	0.12 ± 0.00	0.11 ± 0.01
BV/TV	0.60 ± 0.03	0.60 ± 0.01	0.63 ± 0.01¹	0.58 ± 0.01
Ct. TMV	743.5 ± 56.9	787.4 ± 21.5	831.0 ± 13.2	753.0 ± 16.2¹
Ct. TMD	1262.9 ± 18.9	1324.1 ± 20.8	1304.3 ± 11.0	1258.6 ± 13.4

¹Indicates significant difference between groups P < 0.05. BMC: Bone mineral content; BMD: Bone mineral density; BV: Bone volume; TV: Total volume (bone plus marrow); BV/TV: Bone volume fraction; Tb. Tk: Trabecular thickness; Tb. N: Trabecular number; Tb. TMV: Trabecular material volume; Tb. TMD: Trabecular material density; Ct. TMV: Total cortical material volume; Ct. TMD: Total cortical material density; NOD: Non-obese diabetic; NOD.scid: Syngenic non-diabetic.

Citation: Casazza K, Hanks LJ, Clines GA, Tse HM, Eberhardt AW. Diabetes-related impairment in bone strength is established early in the life course. World J Diabetes 2013; 4(4): 145-150
URL: https://www.wjgnet.com/1948-9358/full/v4/i4/145.htm
DOI: https://dx.doi.org/10.4239/wjd.v4.i4.145