Caribbean maitotoxin elevates [Ca2+]i and activates non-selective cation channels in HIT-T15 cells

Figure 4 Non-voltage activated cation current induced by caribbean maitotoxin or pacific maitotoxin in the calcium free extracellular solution. A: Current traces measured before and after caribbean maitotoxin (MTX-C) or pacific maitotoxin (MTX-P) administration at -80, -40, 0 and 40 mV when held at 0 mV; B and C: I-V relationships of MTX-C (B) and MTX-P (C) elicited currents. The solid circles represent current amplitudes measured after MTX-C (B) or MTX-P (C) administration. The open circles represent the current recorded under the control condition; D: Current conductance measured at different test potentials in cells treated with MTX-C or MTX-P.