Caribbean maitotoxin elevates [Ca2+]i and activates non-selective cation channels in HIT-T15 cells

Figure 3 Effect of caribbean maitotoxin and pacific maitotoxin on non-voltage activated cation currents in HIT-T15 cells. Representative traces of cation current elicited recorded at -80, -40, 0 and 40 mV before and after adding caribbean maitotoxin (MTX-C) (A) or pacific maitotoxin (MTX-P) (C). The holding potential was at 0 mV. I-V relationships of MTX-C- and MTX-P-elicited currents are shown in B and D, respectively. The solid circles represent current amplitudes measured after MTX-C (B) or MTX-P (D) administration. The open circles represent the current recorded under the control condition.