Caribbean maitotoxin elevates [Ca2+]i and activates non-selective cation channels in HIT-T15 cells

Figure 2 Effect of caribbean maitotoxin (A) and pacific maitotoxin (C) on voltage gated calcium channels in HIT-T15 cells. Representative barium current traces recorded at 10 mV when held at -70 mV in patch clamp. Extracellular solution contains 40 mmol/L BaCl₂. B and D show I-V relationship of voltage gated calcium currents elicited by caribbean maitotoxin (B) and pacific maitotoxin (D), respectively. Open and solid circles represent values of current before and after application of maitotoxins, respectively.