ApoE isoforms, treatment of diabetes and the risk of coronary heart disease

Table 3 Factors associated with coronary heart disease in the present cohort¹

Factors	Hazard ratio (95% CI)	P value
Male	0.76 (0.33-1.79)	0.54
BMI at enrollment (compared with 22 < BMI < 25) (kg/m2)
BMI ≤ 18.5	0.87 (0.18-4.36)	0.87
18.5 < BMI ≤ 22	1.86 (0.80-4.36)	0.15
25 < BMI ≤ 30	1.60 (0.75-3.41)	0.23
HbA1c	1.19 (1.02-1.38)	0.029
Systolic blood pressure	1.04 (1.02-1.06)	0.0005
Diastolic blood pressure	0.96 (0.92-1.01)	0.06
Total cholesterol	0.99 (0.95-1.04)	0.79
HDL-cholesterol	0.97 (0.92-1.02)	0.21
LDL-cholesterol	1.01 (0.97-1.05)	0.77
Triglyceride	1.00 (0.99-1.01)	0.86
Diabetic retinopathy	2.38 (1.28-4.43)	0.006
Proteinuria	0.71 (0.34-1.48)	0.36
ApoE phenotype (compared with apoE3 homozygosity)
ApoE2	0.93 (0.31-2.80)	0.89
ApoE4	0.69 (0.18-1.79)	0.58

¹Multivariate Cox proportional hazard analysis adjusted with age and smoking status at enrollment. ApoE: Apolipoprotein E gene; HDL: High density lipoprotein; LDL: Low density lipoprotein.