Editorial
Copyright ©2011 Baishideng Publishing Group Co.
World J Diabetes. Feb 15, 2011; 2(2): 19-23
Published online Feb 15, 2011. doi: 10.4239/wjd.v2.i2.19
Table 1 Anti-obesity drugs[7]
DrugMechanism of actionEffect on weightSide effects
PhentermineReducing food intake: sympathomimetic amine3.6 kg at 6 moHeadache, insomnia, irritability, palpitations and nervousness
DiethylpropionAs above3.0 kg at 6 moAs above
FluoxetineReducing food intake: selective serotonin reuptake inhibitor4.74 kg at 6 mo, and 3.15 kg at 1 yearAgitation and nervousness
SibutramineReducing food intake: combined norepinephrine and serotonin reuptake inhibitor4.45 kg at 1 yearHeadache, insomnia, dry mouth and constipation. Long term treatment increases the risk of major adverse cardiovascular events
OrlistatReducing fat absorption: lipase inhibitor2.59 kg at 6 mo and 2.89 kg at 1 yearDiarrhoea, flatulence, bloating, abdominal pain and dyspepsia
RimonabantReducing food intake: selective CB1 receptor blocker5.1 kg at 1 yearNausea, dizziness, arthralgia and diarrhoea