Effect of ranibizumab on diabetic retinopathy via the vascular endothelial growth factor/STAT3/glial fibrillary acidic protein pathway

Figure 8 Immunohistochemical imaging and the ratio of the number of type IV collagen-positive strands, retinal cells, and area of retinal cells. A: Immunohistochemical imaging of retinal tissues in Sprague-Dawley rats (magnification: 100 ×). B-D: Ratio of the number of type IV collagen-positive strands, retinal cells, and area of retinal cells during the sixth, eighth, and tenth weeks, respectively. The white arrows indicate type IV collagen-positive strands. The yellow arrows indicate areas of vascular permeability. The orange arrows indicate vascular buds. All results are expressed as the mean ± SD. ^aP < 0.05. ^bP < 0.01. ¹P vs F group. ²P vs B group. ³P vs D group. AT-IV: Anti-IV; CSs: Collagen strands; DAPI: 4’,6-diamidino-2-phenylindole; FITC: Fluorescein isothiocyanate; TL: Tomato lectin; RFC: Retinal cell.