Risks of liver cirrhosis, hepatocellular carcinoma, hepatic-related complications, and mortality in patients with type 2 diabetes in Taiwan

Table 2 Overall incidence densities and relative hazards of cirrhosis of the liver, hepatocellular carcinoma, hepatic-related complications, and mortality in patients with type 2 diabetes and nondiabetic subjects

Variables	Non-diabetic group			Patients with T2D			Model 1 crude HR (95%CI)	Model 2 adjusted HR (95%CI)2
	No. of patients	No. of events	Incidence densities (per 10000 person-years) (95%CI)1	No. of patients	No. of events	Incidence densities (per 10000 person-years) (95%CI)1
Cirrhosis of the liver	648746	2697	6.32 (6.08-6.56)	33184	385	17.20 (15.48-18.92)	2.71 (2.43-3.01)	1.45 (1.30-1.62)
Hepatocellular carcinoma	648746	803	1.88 (1.75-2.01)	33184	183	8.15 (6.97-9.33)	4.33 (3.69-5.09)	1.81 (1.52-2.15)
Hepatic complications	648746	1436	3.36 (3.19-3.54)	33184	207	9.22 (7.96-10.48)	2.75 (2.37-3.18)	1.87 (1.60-2.19)
Hepatic mortality	648746	517	1.21 (1.11-1.31)	33184	134	5.96 (4.95-6.97)	4.73 (3.91-5.72)	2.08 (1.70-2.54)

¹Based on the Poisson assumption.

²Based on the Cox proportional hazard regression model adjusted for age, body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, triglyceride, high-density lipoprotein cholesterol, alanine transaminase, and aspartate transaminase as continuous variables, with sex and regular exercise as categorical variables.

T2D: Type 2 diabetes; HR: Hazard ratio.