Systemic immune indicators for predicting renal damage in newly diagnosed type 1 diabetic children

Table 3 Predictive significance of biomarkers for early kidney damage in children with type 1 diabetes mellitus

Indicator combination	AUC	95% confidence interval	P value	Threshold	Sensitivity, %	Specificity, %
SII	0.72	0.612-0.826	< 0.001	624.015	59.6	92
NLR	0.7	0.603-0.804	< 0.001	2.17	55.8	80
PLR	0.71	0.604-0.811	< 0.001	127.51	53.8	94
SII + NLR	0.77	0.676-0.869	< 0.001	0.645	55.8	98
SII + PLR	0.79	0.695-0.887	< 0.001	0.502	69.2	90
NLR + PLR	0.73	0.627-0.828	< 0.001	0.466	63.5	84
SII + NLR + PLR	0.79	0.690-0.883	< 0.001	0.604	63.5	96

AUC: Area under the curve; SII: Systemic immune inflammation index; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio.