Systemic immune indicators for predicting renal damage in newly diagnosed type 1 diabetic children

Table 2 Correlation of systemic immune inflammation index, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio with various indicators

Indicator	SII, r	SII, P	NLR, r	NLR, P	PLR, r	PLR, P
Age, months	0.12	0.228	0.055	0.585	0.084	0.4
SBP, mmHg	0.121	0.226	0.145	0.147	0.093	0.35
DBP, mmHg	0.119	0.232	0.200a	0.044	0.048	0.634
Blood urea, mmol/L	0.121	0.226	0.092	0.36	0.129	0.195
Blood creatinine, μmol/L	0.089	0.372	0.168	0.091	0.117	0.24
TC, mmol/L	0.135	0.177	0.104	0.297	0.268b	0.006
TG, mmol/L	0.270b	0.006	0.188	0.058	0.227a	0.022
HDL, mmol/L	-0.091	0.362	0.092	0.358	0.154	0.123
LDL, mmol/L	0.111	0.266	0.056	0.573	0.177	0.075
HbA1c, %	0.200a	0.044	0.129	0.197	0.176	0.077
eGFR, mL/minute/1.73 m²	-0.064	0.521	-0.183	0.066	-0.054	0.588
UACR, mg/g	0.552b	< 0.001	0.413b	< 0.001	0.300b	< 0.001
ALT, U/L	-0.076	0.451	0.045	0.65	-0.064	0.522
AST, U/L	0.012	0.908	-0.067	0.501	0.13	0.194
BMI, kg/m²	-0.008	0.933	-0.003	0.973	-0.031	0.755
C-peptide, nmol/L	0.063	0.529	-0.151	0.129	-0.084	0.401
Insulin, mU/L	-0.052	0.604	-0.036	0.716	0.045	0.653
Family history	0.086	0.391	0.032	0.753	0.054	0.592
C-reactive protein, mg/L	0.151	0.131	0.034	0.738	0.063	0.529

^aP < 0.05.

^bP < 0.01.

“r” denotes the correlation coefficient. “P” denotes the P value. SII: Systemic immune inflammation index; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; TC: Total cholesterol; TG: Triglycerides; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; HbA1c: Glycated hemoglobin; eGFR: Estimated glomerular filtration rate; UACR: Urinary albumin-to-creatinine ratio; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BMI: Body mass index.