Aucubin mitigates the elevation of microglial aerobic glycolysis and inflammation in diabetic neuropathic pain via aldose reductase

Table 1 The binding energy of potential targets and contacts (kcal/mol)

Potential targets	Affinity (kcal/mol)	Contacts
ACE	-4.37	ALA-356 ASP-358
MMP2	-7.35	ALA-136 LEU-137 HIS-120 ARG-149
MMP9	-7.35	ALA-189 PRO-246 ALA-242 LEU-243 ARG-249
SI	-3.09	GLU-687 ARG-682 ILE-763 ASP-796 GLU-678
AKR1B1	-9.35	ALA-299 LEU-300 SER-302
MGAM	-4.64	CYS-15 PHE-161 ASN-71
HK1	-2.22	ASP-648
MMP1	-5.5	GLU-135 LYS-151 PHE-149 SER-142
IL-2	-4.43	GLU-60 ASN-90 SER-87 GLU-67
STAT3	-2.78	TYR-686 LYS-573 ALA-578 LEU-577 LEU-579