Single-nucleotide polymorphisms in genes involved in folate metabolism or selected other metabolites and risk for gestational diabetes mellitus

Table 4 Gene-gene interaction model of 10 single-nucleotide polymorphisms related to folate metabolism enzymes on risk for gestational diabetes mellitus

Number of sites	The best model	Tr.BA1	Te.BA2	P value	CVC3
1	rs202676	0.5338	0.5016	0.172	8/10
2	rs1801133 rs408626	0.5599	0.5015	0.623	7/10
3	rs1801133 rs408626 rs202676	0.5874	0.4955	0.623	6/10
4	rs1801133 rs408626 rs202676 rs1801394	0.6339	0.5568	0.172	9/10
5	rs1801133 rs408626 rs202676 rs1801394 rs1051266	0.6935	0.5053	0.623	10/10

¹Training Bal.Acc, training balanced accuracy, the accuracy in the training set, with a range of 0-1, where the larger the value, the higher the accuracy.

²Testing Bal.Acc, testing balanced accuracy, the accuracy in the testing set, with a range of 0-1, where the larger the value, the higher the accuracy.

³Cross-verifying consistency.

CVC: Cross-validation consistency.